POS1378 ARTHRITIS IN PATIENTS WITH FAMILY MEDITERRANEAN FEVER

Background Familial Mediterranean fever (FMF) is an inherited autoinflammatory disease characterized by recurrent episodes of and serositis. Arthritis one the most common attack manifestations. in FMF usually form acute mono- or oligoarthritis large joints lower extremities. While attacks arthritis heal without causing permanent deformity, severe, long-lasting chronic can last for months even years result deformity. Objectives In this study, we described characteristics joint involvement a single cohort. Methods The medical records patients with from our cohort 2350 who were diagnosed familial retrospectively scanned through files hospital database. prevalence, demographic information, genetic test results, clinical features, features involvement, treatments responses, phase values remission periods, family history recorded. Results 953 (n=953) total had arthralgia (40%). male/female ratio was found to be 0.49 (male n=316, female n=637). number underwent testing 787 (82%), 702 (89%) these mutations MEFV gene. pathogenic mutation M694V rate 43%. Concomitant diseases their frequencies are shown Table 1, accompanying spondylarthritis at 27%. present first 55% (n=531), while ongoing 45%. duration between 24-96 hours 77% (n=837) patients, longer than 96 23% (n=116). finding exercise-related leg pain. Family 61% (n=580). 73% (n=696) involved ankle 51% knee (n=492). incidence sacroiliitis 14% (n=142). As joints, 91% oligoarthritis. Asymmetric detected patients. Red %73 study group. HLA-B27 examined 185 24 them positive (12%). It that 43% treatment changes due arthritis. Colchicine dose increases performed 32% NSAIDs started 21%, corticosteroids 15%, DMARDs 12%, anti-TNF 10%, anti-IL-1 8%. mean colchicine as 1.56 ± 0.5 mg. Unresponsiveness 21% (n=122). 1. Conclusion diagnosis should definitely considered people red mono-oligoarthritis One important short effort-related pain symptom suggest FMF. arthritis, required unresponsiveness higher other types. spondyloarthropathy FMF, similar. differential inflammatory low back Disclosure Interests None declared